Introduction
Knee osteoarthritis (OA) is a common condition causing pain, stiffness, and reduced mobility for millions worldwide. While traditional treatments like pain medications and physical therapy help manage symptoms, recent advances have introduced breakthrough therapies that can significantly improve outcomes.
In this article, we’ll explore 5 breakthrough knee osteoarthritis treatments changing the landscape of care. Whether you’re newly diagnosed or struggling with persistent knee pain, these emerging options could offer fresh hope for lasting relief and improved quality of life.
1. Genicular Artery Embolization (GAE)
Genicular Artery Embolization is a minimally invasive procedure designed to reduce inflammation and pain by blocking specific arteries supplying the knee. By targeting the source of inflammation, GAE has shown promising results in decreasing pain and improving knee function without surgery.
Why it matters:
Patients undergoing GAE report significant knee pain relief and better quality of life lasting over a year post-treatment. This therapy is particularly beneficial for those who aren’t candidates for knee replacement surgery.
2. Arthrosamid® Injections
Arthrosamid® is a newly introduced non-biodegradable hydrogel injectable implant available in the UK. It cushions the joint internally, providing mechanical support and reducing the friction that worsens osteoarthritis pain.
Why it matters:
Unlike traditional hyaluronic acid injections, Arthrosamid® offers longer-lasting cushioning, which may lead to sustained pain relief and improved joint function.
3. Stem Cell Therapy
Stem cell therapy uses the patient’s own cells to promote healing and regeneration of damaged cartilage in the knee. While still under research, early studies show potential in slowing OA progression and reducing pain.
Why it matters:
This biological approach targets the root cause of cartilage breakdown, offering hope for tissue repair rather than just symptom management.
4. Platelet-Rich Plasma (PRP) Therapy
PRP therapy involves injecting concentrated platelets from your own blood into the knee joint to stimulate healing and reduce inflammation. This treatment has gained popularity due to its minimally invasive nature and promising pain relief results.
Why it matters:
PRP may delay the need for knee replacement surgery by enhancing natural healing processes.
5. Wearable Joint Support Technology
New wearable devices designed for knee OA combine support braces with smart technology that monitors joint movement and provides feedback to improve gait and reduce strain.
Why it matters:
These innovative supports not only stabilise the knee but also encourage healthier movement patterns, potentially reducing pain and improving function over time. It will be interesting to see how these could be integrated into treatment.

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Conclusion
Knee osteoarthritis treatment is rapidly evolving beyond traditional painkillers and physical therapy. Breakthroughs like Genicular Artery Embolization, Arthrosamid® injections, and regenerative therapies are opening new doors for effective knee pain relief and improved joint health.
If you or a loved one suffers from knee OA, staying informed about these emerging treatments can empower you to make better decisions and seek the care that best fits your needs.
Take care, Helen
Helen Manders BSc (Hons) MCSP HCPC
Chartered Physiotherapist Treating Arthritic Knees Since 2001